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KMID : 1103720110640030203
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Journal of the Korean Society of Radiology
2011 Volume.64 No. 3 p.203 ~ p.211
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Comparison of 3D TOF MRA with Contrast Enhanced MRA in Intracranial Atherosclerotic Occlusive Disease
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Choi Jin-Ha
Lim Soo-Mee
Kim Yoo-Kyung
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Abstract
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Purpose: We compared diagnostic performance of 3D Time of flight MRA with contrast-enhanced MRA to detect and quantify intracranial atherosclerotic occlusive disease.
Materials and Methods : From April 2007 to December 2009, we enrolled 95 patients with clinically suspected intracranial atherosclerotic steno-occlusive disease who had undergone 3D TOF-MRA and CE MRA at 1.5T or 3T with DSA. Two radiologists analyzed the post-processed images using a maximum intensity projection. Intracranial vessels were categorized as distal internal carotid artery, middle cerebral artery or vertebrobasillar artery. We graded the degree of stenosis and assigned subjects to one of three groups: low grade occlusion (<50%), high grade occlusion (50-99%) and complete occlusion. Using the McNemar test, we compared the results of CE MRA with those of 3D TOF for detecting >50% stenosis using DSA as a reference standard.
Results: CE MRA had 94.2% sensitivity, 88.1% specificity, 51% positive predictive value, 99.1% negative predictive value and 88.8% diagnostic accuracy for detecting >50% stenosis; In contrast, 3D TOF-MRA showed 94.2% sensitivity, 91.6.1% specificity, 59.8% positive predictive value, 99.1% negative predictive value and 91.9% diagnostic accuracy. Sensitivity and specificity of CE MRA were not significantly different than sensitivity and specificity of 3D TOF MRA (p >0.05).
Conclusion: 3D TOF-MRA provides comparable diagnostic performance with CE-MRA for diagnosis intracranial atherosclerotic disease.
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KEYWORD
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Intracranial Arteriosclerosis, Cerebral Angiography, Magnetic Resonance Angiography
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